Platelet-Rich Plasma (PRP) therapy uses your body’s own concentrated healing factors to repair damaged tendons, joints, and ligaments without surgery. It is among the most extensively researched regenerative treatments in orthopedics today. Dr. Reza Jazayeri, a double board-certified orthopedic surgeon specializing in sports medicine, offers PRP therapy to patients throughout the Greater Los Angeles area.
The quality of results depends heavily on how PRP is prepared and delivered. Not all PRP is created equal. PRP quality is not just about the machine used; it is the sum of every decision made before, during, and after the injection.
Not all PRP is created equal
PRP quality is not just about the machine used, it is the sum of every decision made before, during, and after the injection. Dr. Jazayeri’s protocol addresses each of these variables systematically, because the difference between ordinary PRP and optimized PRP can mean the difference between a modest result and a meaningful, lasting one.
PRP Overview
PRP harnesses your body’s own concentrated healing factors to repair damaged tendons, joints, and ligaments, without surgery. It is among the most extensively researched regenerative treatments in orthopedics today, and the quality of results depends heavily on how it is prepared and delivered.
The PRP Quality Chain — Every Step Matters
1. Pre-procedure optimization
Nutritional status, BCAA/XR supplementation, pre-exercise conditioning
2. Blood draw technique & volume
Needle gauge, anticoagulant ratio, draw volume — all affect platelet yield
3. Centrifuge technology
Arthrex Angel System with real-time optical sensing for exact platelet targeting
4. Precision delivery
Ultrasound-guided injection directly into the pathology
5. Post-injection protocol
Heat not ice, NSAID avoidance, BCAA/XR continuation, structured PT program
Watch The Angel® System Animation: The Angel® system offers customized PRP formulations from whole blood or bone marrow aspirate.
Growth Factors in PRP
- PDGF – Platelet Derived Growth Factor, cell recruitment & proliferation
- TGF-β – Transforming Growth Factor Beta, tissue remodeling & repair
- VEGF – Vascular Endothelial Growth Factor, new blood vessel formation
- IGF-1/2 – Insulin-like Growth Factors, cell survival & growth
- EGF – Epidermal Growth Factor, tissue regeneration
- FGF – Fibroblast Growth Factor, collagen synthesis
- IL-8 – Interleukin-8, healing signal coordination
Conditions We Treat with PRP
- Partial Rotator Cuff Tears – High-grade partial and intrasubstance tears that haven’t responded to conservative care.
- Meniscus: Best for Degenerative Tears: Less Pain, Delay or Avoid Surgery
- Knee Osteoarthritis – 30+ Level 1 trials show PRP superior to steroid and hyaluronic acid injections.
- Tennis Elbow – Lateral epicondylitis that has failed conservative care. PRP shows superior long-term results.
- Other Conditions – Achilles tendinopathy, shoulder OA, and many more.
After Your PRP Injection
What to do
Apply a warm compress for comfort and blood flow. Take Tylenol (acetaminophen) for pain. Rest from strenuous activity for 1 week. Continue BCAA/XR as directed. Follow your PT program when cleared by Dr. Jazayeri.
What to avoid
Ice — constricts blood flow and suppresses the healing response PRP depends on. NSAIDs (aspirin, ibuprofen, naproxen, Aleve) for at least 2 weeks. No strenuous sports for 1 week.
The PRP Process — Step by Step
1. Pre-procedure optimization
Following Dr. Jazayeri’s protocol, you will have completed a 20-minute vigorous exercise session and taken your BCAA/XR supplement 90–120 minutes before arrival — priming your platelets to be more numerous and biologically active before the blood is even drawn.
2. Blood Draw
A small amount of blood, similar to a routine lab test, is drawn from your arm. The draw volume, needle gauge, and anticoagulant ratio are all controlled to preserve platelet integrity before centrifugation.
3. Centrifugation with the Arthrex Angel System
The blood is processed in the Arthrex Angel System — the most advanced PRP centrifuge available. Three optical sensors read the spinning blood in real time, detecting the precise boundary between cell layers and automatically stopping collection at the exact platelet concentration target. This precision is not possible with standard bedside centrifuges operating on fixed timing alone.
4. Ultrasound-guided injection
PRP is injected using real-time ultrasound imaging, not a blind injection guided by surface landmarks. The needle tip is visible on screen throughout the procedure, ensuring PRP is deposited exactly where the pathology exists, not in nearby tissue.
5. Post-injection protocol — heat, not ice
Apply a warm compress or heating pad — not ice. Heat promotes vasodilation, increasing blood flow to the treated site and delivering the oxygen and nutrients that activated platelets need. Ice causes vasoconstriction, reduces local blood flow, and dampens the inflammatory healing cascade that PRP is specifically designed to harness. Inflammation here is not the problem, it is the mechanism of healing.
6. Recovery, XR supplementation & physical therapy
Continued BCAA/XR supplementationsupports the collagen synthesis phase of healing. A structured PT program is prescribed at the appropriate time to guide tissue remodeling and ensure new collagen forms in the correct load-bearing orientation.
Watch Cellular Components and Growth-Factor Content of PRP From the Angel® cPRP System
Recovery Timeline After PRP Therapy
Recovery after PRP therapy follows a structured timeline. For the first week, you should rest from strenuous activity. Apply a warm compress or heating pad, not ice.
Heat promotes vasodilation, increasing blood flow to the treated site and delivering the oxygen and nutrients that activated platelets need. Ice causes vasoconstriction, reduces local blood flow, and dampens the inflammatory healing cascade that PRP is specifically designed to harness. Inflammation here is not the problem.
It is the mechanism of healing. You may take Tylenol (acetaminophen) for pain. Avoid NSAIDs such as aspirin, ibuprofen, naproxen, and Aleve for at least two weeks.
Continued BCAA/XR supplementation supports the collagen synthesis phase of healing. A structured physical therapy program is prescribed at the appropriate time to guide tissue remodeling. It ensures new collagen forms in the correct load-bearing orientation.
What To Expect During Your PRP Therapy Session
Your PRP therapy session at Dr. Jazayeri’s Los Angeles office follows a clear sequence. You will have completed pre-procedure priming with exercise and BCAA/XR supplementation before arrival. Once in the office, a blood draw is performed using controlled parameters to protect platelet integrity.
The blood is immediately processed in the Arthrex Angel System centrifuge. While you wait, the machine’s optical sensors identify the exact platelet-rich layer and concentrate it precisely. The prepared PRP is then injected into the treatment area using ultrasound guidance for accurate placement.
The entire process, from blood draw to completion of the injection, takes less than 30 minutes. You will receive clear post-procedure instructions before leaving, including guidance on heat application, activity restrictions, and medication use.
Frequently Asked Questions About PRP Therapy
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PRP therapy is a treatment that uses a concentrated solution of platelets from your own blood to help heal injuries. It is often used for conditions like tendon injuries and osteoarthritis.
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The process starts with a blood draw, which is then processed to concentrate the platelets. This platelet-rich plasma is injected into the injured area to promote healing.
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PRP therapy is effective for various musculoskeletal issues, including knee osteoarthritis, tennis elbow, and tendon injuries. It is particularly useful for patients who have not found relief from traditional treatments.
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The number of injections varies based on your specific condition and how you respond to treatment. Some patients may see improvement with just one injection, while others might need a series of treatments.
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Your session will involve a blood draw, processing of the blood, and then an injection of the PRP into the treatment area. The entire process usually takes less than 30 minutes.
Why Choose Us For PRP Therapy?
We specialize in Platelet-Rich Plasma (PRP) therapy to help you heal from orthopedic injuries. Dr. Reza Jazayeri, a double board-certified orthopedic surgeon, has over 15 years of experience in sports medicine. His expertise ensures that you receive quality care based on your own body’s healing factors to promote recovery without surgery.
Our PRP process is designed for precision. We use advanced technology to prepare high-quality PRP, maximizing its effectiveness. Dr. Jazayeri’s approach includes a thorough evaluation to determine if PRP is right for you.
We prioritize your comfort and safety, guiding you through every step of the treatment. Choose us for a personalized experience that aims to improve your function and reduce pain.
Meet Dr. Reza Jazayeri
Dr. Reza Jazayeri specializes in sports medicine with expertise in shoulder, knee, and elbow injuries. A Southern California native, Dr. Jazayeri combines an engineering background with elite surgical training, completing his orthopedic surgery residency at the nationally ranked NYU Hospital for Joint Diseases and a sports medicine fellowship at the renowned Kerlan-Jobe Orthopaedic Clinic.
After more than 15 years caring for patients within the Southern California Permanente Medical Group, Dr. Jazayeri joined DOCS Health to expand a practice focused on personalized orthopedic and sports medicine care and surgical excellence. As Director of Longevity at DOCS Health, he leads the development and implementation of optimization protocols and regenerative medicine strategies designed to improve long-term musculoskeletal health and extend healthspan.
His published work includes a 2026 coauthored review of nutritional optimization in spine surgery in the Journal of the American Academy of Orthopaedic Surgeons. View Dr. Jazayeri’s research publications and training.
Dr Jazayeri, first, repaired a torn rotator cuff. I reinjured my shoulder several years later, and he performed a shoulder replacement. I went home the same day as the surgery, I have full range of motion, and I needed next to no pain meds. He’s the best and very well known as such in the Ventura area.
Schedule Your Consultation For PRP Therapy Today
If you are dealing with chronic joint or tendon pain and want to explore Platelet-Rich Plasma (PRP) therapy, schedule a consultation with Dr. Reza Jazayeri. As a double board-certified orthopedic surgeon with over 15 years of experience and fellowship training from the Kerlan-Jobe Orthopaedic Clinic, he brings advanced expertise in regenerative medicine to patients across the Greater Los Angeles area. Dr. Jazayeri’s systematic approach to PRP preparation and delivery reflects his focus on precision at every step.
Virtual consultations are available for patients across California and beyond. Contact the Los Angeles practice today to discuss whether PRP therapy is right for your condition.
Medically reviewed by Reza Jazayeri, M.D. on
